
The tongue and throat cancer is increasing, especially since there are more cases from infections with human papilloma virus (HPV), according to a study conducted in the United States.
The number of people who were diagnosed with oral cancer linked to HPV in 2004 was three times higher than those diagnosed in 1988. This is mainly due, according to the researchers suspect, changes in sexual behavior that helped spread the virus.
HPV (HPV by its acronym in English) is a sexually transmitted virus very common, which can cause genital warts and certain cancers, including cervical or uterine cervix, anus and penis.
“The relationship between HPV and head and neck cancer completely changed our idea of who is at risk, how to treat cancer, prognosis and prevention,” said Maura Gillison of Ohio State University, who led the study published Journal of Clinical Oncology.
Gillison and colleagues examined oral cancer tissue from 271 patients collected over a period of 20 years. The type of cancer examined, called the oropharynx, originates in the back of the tongue, palate, tonsils, or the side of the throat.
The team looked for evidence of HPV infection in the samples and found that HPV-related cases were increasingly common in every decade, while samples that were not linked to the virus were less frequent.
From the results, the researchers conclude that oral cancer linked to HPV affects 26 per million, compared with eight per million in 1988.
Tina Dalianis, a professor at the Karolinska Institute in Sweden, who was not involved in the study, believes the increase in oral cancers “is due to an epidemic of HPV.”
“We believe that sexual habits have changed, and that there is an increase in sexual activity at younger ages, with a change of many more sexual partners in general,” Dalianis told Reuters Health.
The study confirms what the expert had previously found in Sweden, that oral cancers associated with HPV were becoming the dominant form of the disease.
Previously, the snuff had been the main cause of oral cancer, and most cancer cases were HPV negative. Gillison’s team found that HPV-negative oral cancers dropped by half since the 1980s.
HPV-positive cases, representing only 16 percent of oral cancers in the 80, including more than 70 percent in the 2000s. The good news is that people diagnosed with cancer is HPV positive have a better prognosis, and tumors respond better to treatment, Gillison said.
There is also a potential opportunity to avoid using the HPV vaccine, which is approved to prevent cervical cancer and anal, the expert said. If the vaccine can prevent these cancers caused by HPV in the genital area, maybe I can also work for oropharyngeal cancers.

November 7th, 2011
Mark
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